To get the best fruit production yes. Blueberries fruit on the previous years growth and you prune them when they are dormant Nov-Mar.
They don't need much in the first 2-3 years just try to keep the bush open centred and remove any crossing branches.
Subsequent years:
- cut out any dead, dying, diseased, crossing growth
- cut one or two of the oldest canes down to the ground
This way you keep a constant renewal of young growth alongside the fruiting canes. Hope that helps. www.alisonpike.com/blog