Ive used it on nettles growing in the borders - takes around 10 days. I also used it on a bramble, and did several leaves despite the label saying only needed to do one. However, bramble would survive a nuclear blast, I'm sure, so covering my bets. Two weeks later and bramble still alive, but looking a bit lacklustre compared to two weeks ago. I think patience is the key, however, if you want a garden to look pristine all the time, its probably not for you. You would get fed up waiting and just hand pull the weed (but it will be back!).