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Scientific Name(s): Symphytum officinale L., S. asperum Lepechin, S. tuberosum L., Symphytum x uplandicum Nyman. Family
Common Name(s): Comfrey , bruisewort , blackwort , knitbone , radix consolidate , Russian comfrey , slippery root
Therapeutic use of comfrey is limited because of its toxicity. A limited number of clinical trials show short-term efficacy of topically applied, alkaloid-free comfrey preparations in skin
Comfrey is not recommended for internal use because of the hepatotoxic pyrrolizidine alkaloid content. Patients with hypersensitivity or allergic reactions to the plant should avoid external use. Use is contraindicated during pregnancy and lactation, in infants, and in patients with liver or kidney disease.
Contraindicated because of documented adverse effects. Pyrrolizidine alkaloids have abortifacient effects and increase the risk of fatal hepatic veno-occlusive disease. Animal experiments have detected alkaloids in breast milk