Posted: 21/09/2014 at 12:17
As Dove said, a closer photo would help but the large leaved ones look very much like Foxgloves (a wild flower) to me which are biennial (ie they take 2 years to flower, then die) and will send up a tall flower spike next year; I would keep those:
Foxglove seeds will be in the soil and can last for decades so will probably keep coming back forever - if you don't want them, just dig them up when you see them appear.
I think you also have brambles (smaller serrated leaved ones with spiky stems) and those are rather invasive so should be dug up, removing all of the roots if you can:
If you don't want any of these plants, dig the area over. If you don't plant anything else and leave bare soil, weeds will constantly keep appearing, so either plant things you want in the area, or you'll just have to be prepared to keep weeding it.